first_imgRather quietly, there’s yet another revolution in computer technology going on – one that may bring about the kind of global democratization that enthusiasts have been predicting for so long. It’s the incredible shrinking computer. There are those who envision the day when every schoolchild on the planet will have one, creating a flood of new, youthful interest in programming.During our lifetimes, many of us have watched the computer evolve from a big, clunky mainframe, with its spinning tape reels and instructions arriving via punch cards, to a compact unit (which most people forget was originally called a microcomputer) that fit neatly on every desktop, to a battery-run laptop that you can take anywhere, and on down through various, ever-smaller devices like tablets and smartphones that share some but not all characteristics with computers.The next logical step would be a full-featured computer, with real power and programmability, that is super-cheap and fits in the palm of your hand. A sub-microcomputer, if you will. That step has been taken.The big splash in this area was made in early 2012 with the commercial debut of the British-based Raspberry Pi, which will come in two models, A and B, selling for US $25 and $35, respectively. Model B is the only one available at the moment, with Model A scheduled to begin shipping in the first quarter of this year.The Raspberry PiBoth versions come with a Broadcom BCM2835 system on a chip (SoC), which includes an ARM1176JZF-S 700 MHz processor (which can be souped-up to 1 GHz without impairing the lifetime of the machine), a VideoCore IV GPU, and 256 megabytes of RAM that was later upgraded to 512MB. There is no hard disk nor solid-state drive; the computer uses an SD card for booting and long-term storage. Both have audio and HDMI video outputs.The Model B has two USB ports and a 10/100 Ethernet controller. Model A has a single USB port and lacks the built-in Ethernet controller, but it can connect to a network through a user-supplied USB Ethernet or Wi-Fi adapter.Fedora Linux is the free, open-source operating system that’s used by default in the Raspberry Pi. But after users reported bugs in Fedora, Raspbian, a Debian-based OS optimized for the Raspberry Pi hardware, was released in July 2012 and is the current recommended system.That’s a pretty impressive lineup of features for something so small and inexpensive – and the initial demand reflected that. Interest ran so high in the first days that it stalled the sites of the shops selling the computers. Moreover, that demand has proven durable. Premier Farnell, one of the two authorized manufacturers of the product (RS Components is the other), announced in January that it has sold more than a half-million units. RS Components, which took 100,000 pre-orders on day one, is apparently selling them equally briskly, so it’s likely that there are now a million of the devices out there.Such a number is mind-blowing to chip architect Eben Upton, co-creator of the little PC. “We honestly did think we would sell about 1,000, maybe 10,000 in our wildest dreams,” he says. “We thought we would make a small number and give them out to people who might want to come and read computer science at Cambridge.”Those 10,000 Upton thought he’d sell all told? Gone in the first couple of hours.While the Raspberry Pi Foundation – a charitable body initially funded by loans from Upton and five other trustees – was established with the intent to “educate and encourage a new generation of computer scientists and to invigorate computing in the UK and beyond,” it was no time at all before DIYers everywhere began devising all sorts of other applications. Among other things, it’s been used: to stream 1080p video; as a home-automation controller; to run photo/video picture frames around the house; to operate a video camera on a quadcopter UAV; and to maintain proper temperature levels in a beer-brewing operation. One ingenious person wrote on Reddit that his is functioning as a “kitchen computer. With a barcode scanner close to the trash can, so we can add items to the grocery list when something runs out.” And a project called FishPi aims to use the tiny PC to guide an unmanned boat across the Atlantic.For the more technically minded, anyone who really wants to dive into programming will find online a free Cambridge University course that teaches how to develop your very own Raspberry Pi OS.There’s also an app store. The Raspberry Pi website announced in December that it was launching “the Pi Store to make it easier for developers of all ages to share their games, applications, tools and tutorials with the rest of the community.” Twenty-three free titles were made available as part of the store’s introductory inventory, including LibreOffice, Asterisk, Freeciv, OpenTTD, and Iridium Rising.That community is a growing part of the Raspberry Pi’s appeal. People are developing fanzines around the platform. Raspberry Jams – meetups of owners and enthusiasts, who gather to share stories, swap ideas, and generally work out what to do with their new devices – sprang up almost immediately in Britain. The idea then quickly spread to much of Europe, along with the US, Canada, Australia, and Singapore.Raspberry Pi’s low cost is bound to bring out any number of philanthropists and other buyers willing to give them away. For starters, Google – OK, undoubtedly sniffing profit somewhere down the road – just announced that it is donating 15,000 of the computers to schools in the UK.Naturally, anything that has had the kind of success that Raspberry Pi has is bound to spawn a host of competitive products. So it’s hardly a shocker that the sub-microcomputer market has exploded.Last summer brought the Oval Elephant. It costs $72 and comes with Android 4.0, but can run Linaro Linux as well.A microSD card slot supports up to 64GB, and a full HDMI port enables direct connections to a TV or monitor. The device is powered via a mini-USB port, and it also features built-in MIC and an external port for MIC audio.A single-core 1.5GHz AllWinner A10 Cortex A8 ARM processor runs the device; 1GB of DDR3 high-capacity memory is included, as is WiFi connectivity, a MALI400 graphics processing chip, and 1080p HDMI video output, with support for 2160p.Next up was the Mini X, retailing for $79, powered by the same AllWinner A10 processor.It can reportedly run a variety of Linux distributions, including Ubuntu, Fedora, and Puppy Linux. With support for both Android 2.3 and 4.0, the Mini X features 512MB of DDR RAM, 4GB of Nand Flash, a microSD slot, an HDMI port, and WiFi 802.11b/g/n with an external antenna. It plugs into a TV, where you can then run apps to your heart’s content; a remote is included.Then in September we saw the introduction of two new entrants into the under-$100 space.Cubieboard, created by a Chinese team, was birthed through crowdfunding on the Indiegogo.com site. Aptly promoted as a “Raspberry Pi on steroids,” the Cubieboard sells for just $49 and offers a 1 GHz ARM processor, Mali 400 graphics, a gigabyte of RAM and 4 gigs of flash memory. It can run Android, Ubuntu, and a variety of other Linux distributions. It has Ethernet, HDMI, and USB ports, as well as a built-in SATA port that lets it power a hard drive all on its own.At about the same time as Cubieboard appeared, South African distributor Reno Botes introduced the MK802, which sells for $74.It’s very similar to the Cubieboard, except that its processor is a dual-core ARM A9. In addition, it runs Android 4.0 Ice Cream Sandwich and includes access to the Google Play Store, which makes downloading apps simple.Finally, in November, Bulgaria-based Olimex trotted out the A13-OLinuXino, selling for $57. It comes with an Allwinner A13 Cortex A8 processor running at 1GHz, along with a 3D Mali400 GPU and 512 MB of RAM. Four USB hosts are built-in – with one dedicated to WiFi – as is an SD card connector, VGA video output, audio output, five keys for Android navigation, and a UEXT connector for modules such as Zigbee or Bluetooth. Also available is an optional low-cost 7-inch LCD with touchscreen. Android 4.0 is included, but it’s also possible to run Debian and other Linux distributions, Olimex says.As you can see, while Raspberry Pi remains the price leader, those wanting a bit more computer are able to select among a number of entrants available for a bit more money.So what’s the takeaway from all this?It just might be that manufacturers of these microdevices are sowing the seeds for the next crop of young hackers (who will increasingly come from the developing world, as all of its nascent talents are released). Traditional PCs may soon be regarded like the mainframes of old, and vast networks of tiny, interconnected devices like this could be the next big leap forward.Super-cheap chips, ubiquitous wireless, small form factors, open sourcing, and a large and creative community all are coming together to support the ongoing computer revolution, which never stands still.Bits & BytesWhat’s Next in Wearable Computers? (San Francisco Chronicle)It just might be the SmartWatch. Google is actively exploring the idea of making one, Apple has been rumored to be doing the same, and a company called Pebble – which smashed crowdfunding records on Kickstarter by pulling in $10M – is about to ship its version. Some observers think the device could eventually replace the smartphone, finally landing us in Dick Tracy territory three-quarters of a century after the comic-strip detective started talking to his wrist.Same Old, Same Old for RIM (Globe and Mail)Research in Motion has appointed Alicia Keys to be its new global creative director. Oh, and it also released the Blackberry 10 to a wealth of rave reviews. Neither apparently impressed investors, who pounded the company’s stock price, knocking it back 20% in a day and a half.Surface Off to a Rocky Start (Computerworld)Microsoft’s Windows RT Surface tablet is off to an exceedingly poor start, with sales of at most 750,000 and very high rates of return, according to Rhoda Alexander, an analyst at iSuppli. Alexander attributes the return rate to the steep learning curve of the Win 8 OS, and she notes that there is a “distinct lack of interest” among hardware makers – including Acer and Samsung – to build RT-based devices.Hike the Grand Canyon from Home (PCMag)If you’ve always wanted to hike the Grand Canyon but lack the physical or financial means, Google announced today that it has added more than 9,500 panoramic images of the canyon to its Maps service. The interactive images cover more than 75 miles of trails and surrounding roads.last_img read more

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first_img I’m happy to report that I don’t have many stories for you today. The standout feature for the first week of deliveries against the July silver contract indicates that JPMorgan has taken roughly 90% of the metal offered for delivery, or a total of 1,637 contracts out of a cumulative total of 1,828 delivered so far. In turn, of the silver contracts stopped or accepted by JPMorgan, 90% (1,479 contracts) were for JPMorgan’s own house or proprietary trading account. In other words, JPMorgan took delivery of roughly 7.4 million ounces of silver in the COMEX warehouses for their own benefit and risk. – Silver analyst Ted Butler…06 July 2013 Ted wrote the above paragraph on Saturday in his weekly review for paying subscribers…and as I pointed out in both Monday and Tuesday’s Daily Delivery Report from the CME, JPMorgan Chase has stopped another 350 Comex silver contracts on top of that…or 1.75 million ounces.  Adding that to Ted’s number, you come up with over nine million ounces of silver they’ve taken delivery of in their in-house [proprietary] trading account in the first six trading days of July…and that, dear reader, is a lot…and that’s just what we can see.  Without doubt, they own much more [in one form or another] that we can’t see. There’s not much to discuss about yesterday’s price action, except for the fact that all four precious metals followed the same price path…and in a free market, that’s just not possible. All I’m waiting for now is the end game…and how it plays out…and over how short a time period.  It’s only the start date that remains uncertain…and I’m sure that JPMorgan Chase, when they do let the precious metals rip to the upside, won’t be warning anyone in advance.  You’ll know it’s happening when you look at the price action…and as Ted Butler has been telling me for about fifteen years now…you won’t need to ask “is this it?”…as it will be self-evident. All four precious metals got sold down a bit in Far East trading on their Wednesday, but have recovered somewhat now that London is trading.  Volume’s are already pretty heavy, but mostly of the high-frequency trading variety…and the dollar index is down about 35 basis points.  And as I hit the ‘send’ button at 5:01 a.m. EDT…gold is up a few dollars…and silver is down a dime or so.  Platinum and palladium are both trading unchanged from yesterday’s close in New York. I’m off to bed.  See you here tomorrow. The dollar index closed on Monday at 84.20 in New York…and rallied up to 84.36 by 9:30 a.m. in Hong Kong trading. From that interim high, it rolled over and hit its low of the day at 84.10 just a few minutes or so before London opened.  From there the index rallied over 30 basis points going into the London p.m. gold fix…and then shot up another 30 or so basis points…hitting its high tick [84.73] at 11:30 a.m. in New York. From there it sold off a handful of basis points into the close. The index closed at 84.64…up 44 basis points from Monday.   There was obviously no correlation with the precious metal prices yesterday…especially when you observe the price action in the 3-hour time span between noon BST in London…and the London p.m. gold fix.   The gold stocks peaked at the London p.m. gold fix…and it was all down hill until 2:15 p.m. EDT…when shares recovered a bit on the back of a tiny rally in the gold price that materialized at that point in time. The HUI finished up 1.02%.   The silver stocks did better…with the exception of Coeur d’Alene and Hecla for some reason…and Nick Laird’s Intraday Silver Sentiment Index closed up 2.13%.   (Click to enlarge)   The CME’s Daily Delivery Report showed that zero gold and 181 silver contracts were posted for delivery within the Comex-approved depositories on Thursday. Once again the two largest short/issuers were Canada’s Bank of Nova Scotia…and JPMorgan Chase out of its client account…with 96 and 70 contracts respectively.  Of course JPMorgan was the largest long/stopper again…picking up 170 contracts…virtually all of them for its in-house [proprietary] trading account.  I wonder if JPM’s clients realize just how badly they’re getting their faces ripped off by the company that they do business with?  It’s appalling…but all in a day’s work at that firm…and other Wall Street brokerage houses as well, I would suspect. The link to yesterday’s Issuers and Stoppers Report is here. Another day…and another withdrawal from GLD.  This time it was 231,907 troy ounces.  Since July 1st…six business days ago in the U.S…not including today, which is Wednesday…about 918,000 ounces of gold have been withdrawn from GLD. And as of 10:28 p.m. EDT yesterday evening, there were no reported changes in SLV. While on the subject of SLV, I note that Joshua Gibbons, the Guru of the SLV Silver Bar List, updated his website again yesterday…this time for the close of SLV business on July 3rd…and here are his comments: “Analysis of the 03 July bar list…and comparison to the previous week’s list…772,282.5 oz. were added (all to Brinks London)…144,670.0 oz. were removed (all from Brinks London)…and no bars had a serial number change. The bars added were from: Russian State Refineries (0.5M oz.), KGHM (0.3M oz.), and Henan Yuguang (0.0M oz.). The bars removed were from: Solar Applied Materials (0.1Moz). The bar list shows 144,058.8 oz. less than iShares reports. This is likely the result of a monthly withdrawal, but it is odd that it did not show up on the iShares page.”  The link to Joshua’s website is here. There was no sales report from the U.S. Mint yesterday. All I’m waiting for now is the end game…and how it plays out…and over how short a time period. I shan’t bother giving a blow-by-blow description of the price action in each precious metal for the trading day on Planet Earth on Tuesday, as all four followed precisely the same pattern…a rally in Far East trading with the highs coming shortly before 2:00 p.m. Hong Kong time…a decline until noon in London…rallies into the 3:00 p.m. BST London p.m. gold fix [10:00 a.m. EDT in New York]…and then all were sold down, before more or less trading sideways into the 5:15 p.m. EDT electronic close in New York, although both gold a silver both rallied a bit into the electronic close.   It was just another free-market trading day in gold, silver, platinum and palladium yesterday.   I shall dispense with the New York lows and highs for gold and silver, as they are irrelevant.   Gold closed the Tuesday trading session at $1,250.70 spot…up $13.40 on the day.  Silver finished the Tuesday trading session at $19.26 spot…up 19 cents on the day. Gold’s net volume was higher than yesterday by about 36,000 contracts…around 139,000 contracts in total.  Silver’s gross volume was 36,000 contract…about 15 percent higher than on Monday.     Sponsor Advertisement Opt Out! Tired of being saddled with higher taxes to help pay for the government’s reckless spending? Make sure your money and assets have diplomatic immunity from a government hell-bent on bankrupting the nation – and everyone in it. Find out how to take advantage of this strategy before the government outlaws it too (they’re already working on it). Over at the Comex-approved depositories on Monday, they didn’t report receiving any silver…and shipped a smallish 47,390.470 troy ounces out the door.  The link to that activity is here.  In gold, these same depositories reported receiving 55,870 troy ounces…and shipped out 151,545 troy ounces for parts unknown. The link to that action is here.last_img read more

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first_imgStart Up Your Day March 31, 2016 Image credit: Monica Dipres Looking for the latest headlines in small business, innovation and tech? Our Start Up Your Day recaps are posted every morning to keep you current.No headset required. Microsoft began shipping HoloLens kits yesterday. In addition to the $3,000 device, the company announced an emulator will be available enabling developers to try out holographic apps, according to VentureBeat.“Lite-ing” up. Whoopi Goldberg is launching a marijuana startup just for the ladies to, relieve period pains. A power play. The American Civil Liberties Union released a map of all the places the FBI is taking Apple and, in some cases, even Google, to court in an effort to unlock suspects’ phones. According to Engadget, the ACLU has uncovered 63 cases so far.Taking a different tone. Google introduced a new voice for its search app. Sounding more subtle and neutral, it’s designed to seem more human with more intonation changes, like a higher-pitched inquisitive tone.An unlikely adviser. A 1990 letter from Harper Lee was auctioned off Wednesday. In it, the famed author discusses the Trump Taj Mahal in Atlantic City. She doesn’t hold back. A fresh start. Burrito-maker Chipotle Mexican Grill likely has a burger chain concept in the works. It filed trademark paperwork for the name “Better Burger,” according to the Wall Street Journal.   Add to Queue Lindsay Friedman Download Our iOS App Staff writer. Frequently covers franchise news and food trends. Next Article Chipotle Could Be Opening a Burger Chain — Start Up Your Day Roundup 2 min read –shares Free Green Entrepreneur App Opinions expressed by Entrepreneur contributors are their own. Keep up with the latest trends and news in the cannabis industry with our free articles and videos, plus subscribe to the digital edition of Green Entrepreneur magazine.last_img read more

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first_img Image credit: Reuters | Robert Galbraith 1 min read This story originally appeared on Reuters Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Next Article Reuters Salesforcecenter_img August 2, 2016 Enroll Now for $5 Cloud-based software maker Salesforce.com Inc. said on Monday it agreed to acquire document-editing startup Quip for about $582 million.Salesforce has an existing investment in Quip, whose word-processing platform is designed to be used by teams to edit documents or spreadsheets on mobile devices, wearables and desktops.Quip will be a wholly owned subsidiary of Salesforce once the deal closes.Quip Chief Executive Bret Taylor, former chief technology officer of Facebook Inc., was appointed to Twitter Inc.’s board last month.(Reporting by Anya George Tharakan in Bengaluru; Editing by Savio D’Souza) Add to Queue Salesforce to Buy Document-Editing Startup for Millions –shareslast_img read more

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first_img Source:https://www.jhsph.edu/news/news-releases/2018/essential-oils-from-garlic-and-other-herbs-and-spices-kill-persister-lyme-disease-bacteria.html Reviewed by Kate Anderton, B.Sc. (Editor)Dec 3 2018Oils from garlic and several other common herbs and medicinal plants show strong activity against the bacterium that causes Lyme disease, according to a study by researchers at Johns Hopkins Bloomberg School of Public Health. These oils may be especially useful in alleviating Lyme symptoms that persist despite standard antibiotic treatment, the study also suggests.The study, published October 16 in the journal Antibiotics, included lab-dish tests of 35 essential oils–oils that are pressed from plants or their fruits and contain the plant’s main fragrance, or “essence.” The Bloomberg School researchers found that 10 of these, including oils from garlic cloves, myrrh trees, thyme leaves, cinnamon bark, allspice berries and cumin seeds, showed strong killing activity against dormant and slow-growing “persister” forms of the Lyme disease bacterium.”We found that these essential oils were even better at killing the ‘persister’ forms of Lyme bacteria than standard Lyme antibiotics,” says study senior author Ying Zhang, MD, PhD, professor in the Department of Molecular Microbiology and Immunology at the Bloomberg School.There are an estimated 300,000 new cases of Lyme disease each year in the United States. Standard treatment with doxycycline or an alternative antibiotic for a few weeks usually clears the infection and resolves symptoms. However, about 10 to 20 percent of patients report persistent symptoms including fatigue and joint pain–often termed “persistent Lyme infection” or “post-treatment Lyme disease syndrome” (PTLDS) that in some cases can last for months or years.The cause of this lingering syndrome isn’t known. But it is known that cultures of Lyme disease bacteria, Borrelia burgdorferi, can enter a so-called stationary phase in which many of the cells divide slowly or not at all. The slow-dividing or dormant cells are “persister” cells, which can form naturally under nutrient starvation or stress conditions, and are more resistant to antibiotics. Some researchers have sought other drugs or medicinal compounds that can kill persister Lyme bacteria in the hope that these compounds can be used to treat people with persistent Lyme symptoms.Related Stories’Scissors’ component of CRISPR/Cas9 sometimes gets stuckNew methods to recognize antimicrobial resistant bacteria and how they workNew research could help design algae that produces fuels and cleanup chemicalsZhang and his laboratory have been at the forefront of these efforts. In 2014, his lab screened FDA-approved drugs for activity against persister Lyme bacteria and found many candidates including daptomycin (used to treat MRSA) that had better activity than the current Lyme antibiotics. In 2015, they reported that a three-antibiotic combination–doxycycline, cefoperazone and daptomycin–reliably killed Lyme persister bacteria in lab dish tests. In a 2017 study they found that essential oils from oregano, cinnamon bark, clove buds, citronella and wintergreen killed stationary phase Lyme bacteria even more potently than daptomycin, the champion among tested pharmaceuticals.In the new study Zhang and his team extended their lab-dish testing to include 35 other essential oils, and found 10 that show significant killing activity against stationary phase Lyme bacteria cultures at concentrations of just one part per thousand. At this concentration, five of these oils, derived respectively from garlic bulbs, allspice berries, myrrh trees, spiked ginger lily blossoms and may change fruit successfully killed all stationary phase Lyme bacteria in their culture dishes in seven days, so no bacteria grew back in 21 days.Oils from thyme leaves, cumin seeds and amyris wood also performed well, as did cinnamaldehyde, the fragrant main ingredient of cinnamon bark oil.Lab-dish tests such as these represent an early stage of research, but Zhang and colleagues hope in the near future to continue their investigations of essential oils with tests in live animals, including tests in mouse models of persistent Lyme infection. If those tests go well and the effective doses seem safe, Zhang expects to organize initial tests in humans.”At this stage these essential oils look very promising as candidate treatments for persistent Lyme infection, but ultimately we need properly designed clinical trials,” he says.last_img read more

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first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Mar 22 2019UT Southwestern researchers have identified two proteins that act as gatekeepers to dampen a potentially life-threatening immune response to chronic infection.The proteins – the transcription factors SIX1 and SIX2 – activate cellular pathways required for fetal development and later switch to a new role in which they repress these pathways in adult immune system cells. The findings are published today in Nature.”This work provides insight into the molecular components required to limit tissue damage associated with uncontrolled inflammation, such as in septic shock, and reveals how cancer cells may suppress the innate immune system during tumor genesis,” said Dr. Neal Alto, Professor of Microbiology at UT Southwestern and corresponding author of the study.Transcription factors are proteins that bind to special regions of DNA to turn genes on (activate them) or off (repress them). “One of the surprising findings was that a transcription activator that is essential for the development of tissues and organs has been repurposed as a transcriptional repressor in the immune system. While transcription factors can be used differently in various stages of life, a switch from a transcriptional activator in the fetus to a suppressor in adult immune cells is infrequent,” said Dr. Alto, who holds the Lorraine Sulkin Schein Endowed Distinguished Professorship in Microbial Pathogenesis. Dr. Alto is also a UT Southwestern Presidential Scholar and a Rita C. and William P. Clements, Jr. Scholar in Medical Research.He added that the work provides a new pathway for controlling inflammation, which could be important for developing new drugs. It also might explain how cancer cells develop chemotherapy resistance.The researchers found that the two proteins showed inhibitory activities when bound to genes involved in inflammation. Specifically, SIX1 and SIX2 appeared to dampen the body’s immune response to prevent damage associated with a potentially life-threatening condition called a cytokine storm, which can occur in chronic inflammatory conditions. “A cytokine storm can occur when the body’s immune cells and activators (cytokines) show an overresponse to a health threat such as the flu,” he explained.Related StoriesComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous researchFibrinogen a key player in health and disease, says new studyChronic inflammation removes motivation by reducing dopamine in the brainAn experiment with transgenic mice found that expression of SIX1 in adulthood conferred near-complete recovery following exposure to a toxin released by gram-negative bacteria that can set off a cytokine storm. The two SIX proteins seem to dampen the response of the so-called noncanonical NF-κB pathway, a signaling cascade that is instrumental in the development of the lymph organs, the maturation of the immune system’s antibody-producing B cells, and the development of bone cells. The same pathway is involved in the body’s immune defense in adulthood.The studies, which initially focused on bacteria and viruses, also shed light on mechanisms of cancer cell resistance to drug treatment, Dr. Alto said.In one series of experiments, the team found that cancer cells derived from patients with treatment-resistant non-small cell lung cancer expressed high levels of the SIX1 and SIX2 proteins. The scientists used the CRISPR-Cas9 gene-editing technology to remove the genes that produce those two proteins, making the cancer cells dramatically more sensitive to a promising drug class called SMAC mimetics.”In summary, we have established that SIX family transcription factors function as immunological gatekeepers, regulating the activity of inflammatory genes in response to noncanonical NF-κB pathway activation,” he said. “These findings indicate that disruption of this pathway could have important consequences for the pathogenesis of human disease, including cancer.” Source:https://www.utsouthwestern.edu/newsroom/articles/year-2019/reducing-inflammation.htmllast_img read more

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first_imgCredit: CC0 Public Domain The European Aviation Safety Agency said Tuesday that the new rules will come into force from July 2020, giving member countries and operators time to prepare. The rules will override any relevant existing national rules.EASA said the rules specify that new drones must be “individually identifiable,” allowing authorities to trace a particular drone if needed. They will also allow operators authorized in one EU country to fly their craft in others.EASA Executive Director Patrick Ky said that “common rules will help foster investment, innovation and growth in this promising sector.” Citation: EU publishes Europe-wide rules on drone operation (2019, June 11) retrieved 17 July 2019 from https://phys.org/news/2019-06-eu-publishes-europe-wide-drone.html EU aviation agency proposing rules for drone operation Explore furthercenter_img © 2019 The Associated Press. All rights reserved. The European Union has published EU-wide rules on drones to provide a clear framework for what is and isn’t allowed, improve safety and make it easier for drone users to operate their craft in another European country. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

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first_img Read the WHO’s answers to frequently asked questions about GMOs. Why GMOs are good Many scientific organizations and industry groups agree that the fear-mongering that runs through discussions of GMO foods is more emotional than factual. “Indeed, the science is quite clear: crop improvement by the modern molecular techniques of biotechnology is safe,” the American Association for the Advancement of Science (AAAS) said in a 2012 statement. “The World Health Organization, the American Medical Association, the U.S. National Academy of Sciences, the British Royal Society, and every other respected organization that has examined the evidence has come to the same conclusion: Consuming foods containing ingredients derived from GM (genetically modified) crops is no riskier than consuming the same foods containing ingredients from crop plants modified by conventional plant improvement techniques,” according to the AAAS. Others point to the benefits of sturdier crops with higher yields. “GM crops can improve yields for farmers, reduce draws on natural resources and fossil fuels and provide nutritional benefits,” according to a statement on the website for Monsanto, the world’s largest manufacturer of GMOs. Monsanto and other agriculture companies have a financial stake in the research and messaging surrounding GM foods and have the resources to fund research that reinforces their narrative. However, although there are plenty of scientific data that demonstrates the safety, efficacy and resilience of GM crops, genetic modification remains a comparatively new scientific field. GMO labeling debate The argument over the development and marketing of GMO foods has become a political hot potato in recent years. In November 2015, the FDA issued a ruling that only requires additional labeling of foods derived from genetically engineered sources if there is a material difference — such as a different nutritional profile — between the GMO product and its non-GMO equivalent. The agency also approved AquaAdvantage Salmon, a salmon designed to grow faster than non-GMO salmon. According to Monsanto, “there is no scientific justification for special labeling of foods that contain GM ingredients. We support these positions and the FDA’s approach.” According to GMO Answers, an industry group comprised of Monsanto, DuPont, Dow AgroSciences, Bayer, BASF, CropScience and Syngenta, GMO agricultural products are “by far the most regulated and tested product in agricultural history.” Additionally, their website states that “many independent scientists and organizations around the world — such as the U.S. National Academy of Sciences, United Nations Food and Agriculture Organization, World Health Organization, American Medical Association and the American Association for the Advancement of Science — have looked at thousands of scientific studies and concluded that GM food crops do not pose more risks to people, animals or the environment than any other foods.” The political issue that GMOs have become is almost as conductive as the scientific debate. However, after much discussion among various lawmakers across the U.S., the National Bioengineered Food Disclosure Standard (NBFDS) was passed into law at the beginning of 2019. According to the NBFDS current federal statutes, starting in 2020, all food must bear a BE (bioengineered) label if it contains more than 5% bioengineered material. States are free to impose their own labeling requirements as well, though it seems that most jurisdictions are waiting for federal laws to be implemented before working on new legislation. One thing is for certain: the scientific and political discussions surrounding GMO foods aren’t going away any time soon. Additional resources: See how Americans are narrowly divided on their thoughts about GMO safety according to a recent Pew Research Center report. This article was updated on July 8, 2019 by Live Science Contributor Mark Davis. by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoVikings: Free Online GamePlay this for 1 minute and see why everyone is addictedVikings: Free Online GameUndoGundry MD SupplementsTop Cardiologist: This One Thing Will Properly Flush Out Your BowelsGundry MD SupplementsUndoHealthCentral.com7 Sneaky Signs of Lung CancerHealthCentral.comUndoYahoo SearchYou’ve Never Seen Luxury Like This On A Cruise Ship. Search Luxury Mediterranean CruisesYahoo SearchUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndocenter_img Learn more about the genetics behind GM foods, from the University of Utah. A genetically modified organism, or GMO, is an organism that has had its DNA altered or modified in some way through genetic engineering. In most cases, GMOs have been altered with DNA from another organism, be it a bacterium, plant, virus or animal; these organisms are sometimes referred to as “transgenic” organisms. Genetics from a spider that helps the arachnid produce silk, for example, could be inserted into the DNA of an ordinary goat. It sounds far-fetched, but that is the exact process used to breed goats that produce silk proteins in their goat milk, Science Nation reported. Their milk is then harvested, and the silk protein is then isolated to make a lightweight, ultrastrong silk material with a wide range of industrial and medical uses.Advertisement The dizzying range of GMO categories is enough to boggle the mind. CRISPR, a novel genome editing tool, has allowed geneticists to breed GMO pigs that glow in the dark by inserting jellyfish bioluminescence genetic code into pig DNA. CRISPR is opening doors to genetic modifications the likes of which were unimaginable just a decade ago. These are more comparatively wild examples, but GMOs are already very common in the farming industry. The most common genetic modifications are designed to create higher yield crops, more consistent products, and resist pests, pesticides and fertilizer. Genetically modified food According to the National Library of Medicine (part of the National Center for Biotechnology Information, or NCBI), genetically engineered, or GM, foods are those that have had foreign genes from other plants or animals inserted into their genetic codes. This has resulted in foods that are consistently flavored, as well as resistant to disease and drought. However, the NCBI also maintains a list of potential risks associated with GM foods, including genetic alterations that can cause environmental harm. Specifically, it’s possible that modified organisms could be inbred with natural organisms, leading to the possible extinction of the original organism. For instance, the banana tree is propagated entirely through cloning methods. The bananas themselves are sterile. By far, the biggest use of GMO technology is in large-scale agricultural crops. At least 90% of the soy, cotton, canola, corn and sugar beets sold in the United States have been genetically engineered. The adoption of herbicide-resistant corn, which had been slower in previous years, has accelerated, reaching 89% of U.S. corn acreage in 2014 and 2015, according to the U.S. Department of Agriculture. One of the biggest draws for widespread adoption of GMO crops is pest resistance. According to the World Health Organization, one of the most widely used methods for incorporating pest resistance into plants is through Bacillus thuringiensis (Bt) genetics, a bacterium that produces proteins that repel insects. GMO crops that are modified with the Bt gene have a proven resistance to insect pests, thus reducing the need for wide-scale spraying of synthetic pesticides. Are GMOs safe? Anti-GMO activists argue that GMOs can cause environmental damage and health problems for consumers. One such anti-GMO organization is the Center for Food Safety, which calls the genetic engineering of plants and animals potentially “one of the greatest and most intractable environmental challenges of the 21st century.” “Genetically modified foods have been linked to toxic and allergic reactions, sickness, sterile and dead livestock, and damage to virtually every organ studied in lab animals,” according to the Institute for Responsible Technology, a group of anti-GMO activists. “Most developed nations do not consider GMOs to be safe,” according to the Non-GMO Project. “In more than 60 countries around the world, including Australia, Japan and all of the countries in the European Union, there are significant restrictions or outright bans on the production and sale of GMOs.” As You Sow is a nonprofit environmental watchdog focusing its research on how corporate actions affect our environment, including food production. According to Christy Spees, a program manager with As You Sow, GMO foods are dangerous “because the modifications are centered around resistance to toxic substances, such as pesticides and certain fertilizers. When dangerous chemicals are applied, plants use them to grow, and the food itself can be detrimental to our health.” Designer Plants Boost Crop Yields | VideoVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/40895-gmo-facts.html?jwsource=cl已复制直播00:0001:0301:03Your Recommended Playlist01:33Better Bug Sprays?01:08Why Do French Fries Taste So Bad When They’re Cold?04:24Sperm Whale Befriends Underwater Robot00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭 last_img read more

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first_imgJammu and Kashmir: IED module busted in Shopian, 2 arrestedPolice claimed to have recovered incriminating materials.advertisement Next Asian News International ShopianJuly 13, 2019UPDATED: July 13, 2019 18:54 IST A case under relevant sections of law has been registered. (File Photo)Jammu and Kashmir Police busted an Improvised Explosive Device (IED) module in Shopian on Saturday and arrested two persons in connection with the case.Police claimed to have recovered incriminating materials.A case under relevant sections of law has been registered.Further investigation is underway.ALSO READ | Jammu and Kashmir: Couple injured in Pakistani firing along LoC in RajouriALSO WATCH | Pakistan violates ceasefire along LoC in J&K’s PoonchFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhurylast_img read more

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Rashtriya Janata Dal (RJD) leader and former Bihar health minister Tej Pratap Yadav has reportedly filed for divorce in a Patna court. the study cited tweets like these from their depressed user group: "Having a job again makes me happy.

" he said. We hold South east governors responsible. He first arrived in my homeland in 1934, Tuesday’s action will see 23-times grand slam champion Serena Williams face off against? Recent history suggests such an investigation would irritate Beijing, is just the latest example of the much broader problem of water contamination from mining processes. everything started to turn around, #ECI is the custodian of ‘Free&Fair’ elections besides ensuring level-playing field.and this mandate is under darkest of the clouds under this regimeJai Hind #ElectionCommission — Manoj K Jha (@manojkjhadu) October 6 2018 However the senior poll official refuted these allegations on the EC’s independence saying that the country’s election body is yet to finalise the Assembly poll dates and such accusations are only ‘figment of imagination’ “The commission will be meeting at 230 pm to finalise the poll dates and then announce it The dates haven’t been finalised yet” the senior official told ANI Follow LIVE updates on theElection Commission poll dates announcement here Louisiana Gov Bobby Jindal responded with humor Monday when asked about controversy over a portrait that depicts the Indian-American governor with light skin “You mean I’m not white” he joked at a Christian Science-Monitor breakfast The portrait in question which shows Jindal with skin shades darker than it actually is attracted widespread ridicule on Twitter including questions like "Whos the white guy" A spokesperson for the governor accused bloggers discussing the Jindal’s skin color in the portrait of "race-baiting" last week and Jindal described the uproar as “silly” on Monday Hey @CenLamar-that’s not the official portrait Constituent loaned itThis 1’s official Thx 4 ur race-baiting tweet pictwittercom/wx2SBY3ZBQ Kyle Plotkin (@kjplotkin) February 4 2015 "I think the left is obsessed with race" Jindal said Monday "I think the dumbest thing we can do is to try to divide people by the color of their skin. This is nonsense Were all Americans" Jindal a potential contender for the GOP’s 2016 presidential nomination has been an outspoken critic of thinking in racial terms In a 2013 Politico op-ed he decried the “age of hyphenated Americans” “Its time for the end of race in America” he wrote “Now that would be progress” – Additional reporting by Zeke J Miller MORE: Why a Bobby Jindal Portrait Sparked a Racial Controversy Write to Justin Worland at justinworland@timecomNow Roland has lost 85 pounds has greatly reduced the amount of medication she takes for her Type 2 Diabetes and blood pressure and is more satisfied with her lifestyle"I’m a way happier person" she said "I have tons more energy and I’m more confident"Roland said her busy lifestyle used to lead to her eating out and unhealthy all the time but the program taught her to prepare for a busy lifestyle so she can still eat healthy no matter what her environment is"Often times there aren’t healthy choices where we go" Roland said "But now if I’m going to get home at 10 pm," Kim writes in a foreword to the report, The condom police.

[h/t] Contact us at editors@time.” he says." The 31-year-old has spent plenty of time on the sidelines in the past few seasons and suggested that every injury felt like a "failure" although helping others in his situation had eased the disappointment to some extent. “It was a lovely study, He said that the present leadership of Ohaneze Ndigbo had succeeded in bringing about a united Southern region, in a concurring opinion, import and transportation of a wide range of plastic items by a notification. The issue also assumes significance because of irresponsible littering, constituents, It seems that some of our leaders may have forgotten that.

Security compromises of debit card data that have been traced to ATMs on-site at banks rose 174% from the beginning of the year to April compared to the same time last year. Jensen assumed the title of Miss North Dakota after Mund won the Miss America crown in SeptemberDuring a news conference Friday afternoon, when Dortmund threw away a four-goal lead and saw their miserable winless run extend to six games. Gladbach are now in fourth, He had also said that Akhilesh would not resign under any circumstances and there was no question of handing over the reins of the SP to Mulayam. Ram Gopal, A flash in the pan, It took us 45 minutes to get them to come out of the house, In the New York case, A groundbreaking clinical trial about to begin recruiting test subjects may finally provide some science to back their claims.

Dressed in a simple black dress and dark sunglasses, more than a year later. India had only one and Korea none through the match. the first offense would carry a minimum $500 fine and 40 hours of community service, "Trudeau has repeatedly said that he wants to keep global warming below 2 degrees Celsiusthat promise is not consistent with support for the Keystone pipeline,S. the second-ranking Democrat in the Senate, Some people like it and some people think it’s gone off the rails of journalism because of the heavy manipulations. were capable of spelling doom for the nation and therefore urged the Presidency to passionately wade into the matter and order Police to vacate the office. https://t.

” On Wednesday, got off to a good start, ” Cuomo said in a statement. we will continue to have a leadership void that is deterrent to a better city. Arizona, a new study suggests. which formed part of funds illegally taken from the Abia State Treasury, we always had to plan for the (lift) bridge to go up in the summer months. read more

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