first_imgSince its launch in 2004, Gentlemen’s Tonic has achieved iconic status with its must-have range of ablutions for men seeking optimum results. PER AQUUM Niyama is the first resort in the Maldives to give men’s bodies the customised attention they demand, with a full range of Gentlemen’s Tonic products and treatments tailored to the tropical setting.At LIME Spa, a full range of face, body and massage treatments and products are carefully selected for each client to promote a sense of relaxation and target all levels of the skin to repair and replenish for a healthy, energised complexion. Facial treatments include Express, Hydration, Detox and Anti-Aging with a variety of body care products, to help maintain a youthful appearance. Deep Tissue Massage releases tension, removes toxins and soothes, thereby re-educating the muscle to operate at full capacity. A popular choice is the signature GT Traveller Massage – a head-to-foot treatment that alleviates the stresses and fatigue caused in particular by travelling.Gentlemen’s Tonic luxury grooming range makes a strong addition to the innovation and adventures found in LIME Spa and throughout “Nature’s Playground” at PER AQUUM Niyama. Visitors to the resort can now expect to see even more handsome, bronzed island gods walking along the white sands – or staring back at them in the mirror.www.peraquum.com/niyama3 Jun 2015 Soothed muscles, boosted beach credibility and statuesque skin await male visitors to PER AQUUM Niyama, thanks to treatments and products designed just for men at the resort’s LIME Spa, using the elite London-based Gentlemen’s Tonic grooming line.last_img read more

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first_imgRoku is reportedly working on plans to file confidentially for an initial public offering, in a move that could see the firm raise up to US$150 million. According to a Wall Street Journal report, which cites people familiar with the plan, Roku has been working to prepare for a potential offering with banks including Bank of America Merrill Lynch and Citigroup.However, the report claims that neither the timing of the stock market floatation or the valuation price Roku will aim for have yet been set.Roku founder and CEO Anthony Wood said back in March 2012, while attending the FT Digital Media conference in London, that “our goal as a company is to go public” after it had raised more financing. He declined to give a timescale for the IPO.Earlier this month, a filing with the Securities and Exchange Commission revealed Roku has raised US$25 million in funding.This came shortly after BSkyB said it had made a further US$0.7 million investment in Roku. At the same time, 21st Century Fox said it had also made a further, undisclosed, equity investment in the firm.In September Roku announced it had sold more than 10 million streaming players in the US since launching in 2008.last_img read more

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first_imgLiberty Global-owned UK cable operator Virgin Media has committed to provide fibre-to-the-premises to at least a quarter of the four million new homes and businesses being added to its network as part of its Project Lightning investment.Virgin Media has said it will connect a total of 17 million premises to its network by 2019. The operator said the move would make it the largest wholly fibre broadband network in the country.The operator has already begun rolling out FTTP in Cambridgeshire and Leicestershire, with work expected to begin soon in West Yorkshire, Devon and East Sussex. Virgin Media issuing new techniques including ‘narrow trenching to deploy fibre at lower cost and with greater speed than has hitherto been the case.“While some companies talk a good game, Virgin Media is putting its money where its mouth is and laying fibre to the premise alongside our superior HFC network – delivering the  fastest widely available broadband speeds,” said CEO Tom Mockridge.“In just over one year we’ve laid enough new cable to stretch all the way from Land’s End to John O’Groats, reaching a quarter of a million more homes and businesses – and there’s much more to come.”last_img read more

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first_imgNielsen-owned Gracenote has launched a new Mobile Video Analytics solution designed to offer insights into the quality and performance of popular mobile video streaming apps.The solution is targeted at mobile operators, TV operators, streaming services and hardware manufacturers, allowing them to understand how mobile app performance impacts user behaviour and attitudes.The offering will also provide engagement metrics so that users can understand how, when and where viewers tune-in  – including information such as average viewing time, network access and speed.“Nielsen has been at the forefront of measuring television and digital video content for decades and the new Gracenote Mobile Video Analytics solution extends our market-leadership position in the mobile streaming space,” said Mike Greenawald, senior vice-president, connectivity for Gracenote.“In a hotly-contested marketplace for subscribers, it is critical to understand the factors that drive engagement and retention. Gracenote Mobile Video Analytics identifies the key video performance factors that enable our customers to gain a competitive edge and make more informed business decisions.”last_img read more

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first_img I’m happy to report that I don’t have many stories for you today. The standout feature for the first week of deliveries against the July silver contract indicates that JPMorgan has taken roughly 90% of the metal offered for delivery, or a total of 1,637 contracts out of a cumulative total of 1,828 delivered so far. In turn, of the silver contracts stopped or accepted by JPMorgan, 90% (1,479 contracts) were for JPMorgan’s own house or proprietary trading account. In other words, JPMorgan took delivery of roughly 7.4 million ounces of silver in the COMEX warehouses for their own benefit and risk. – Silver analyst Ted Butler…06 July 2013 Ted wrote the above paragraph on Saturday in his weekly review for paying subscribers…and as I pointed out in both Monday and Tuesday’s Daily Delivery Report from the CME, JPMorgan Chase has stopped another 350 Comex silver contracts on top of that…or 1.75 million ounces.  Adding that to Ted’s number, you come up with over nine million ounces of silver they’ve taken delivery of in their in-house [proprietary] trading account in the first six trading days of July…and that, dear reader, is a lot…and that’s just what we can see.  Without doubt, they own much more [in one form or another] that we can’t see. There’s not much to discuss about yesterday’s price action, except for the fact that all four precious metals followed the same price path…and in a free market, that’s just not possible. All I’m waiting for now is the end game…and how it plays out…and over how short a time period.  It’s only the start date that remains uncertain…and I’m sure that JPMorgan Chase, when they do let the precious metals rip to the upside, won’t be warning anyone in advance.  You’ll know it’s happening when you look at the price action…and as Ted Butler has been telling me for about fifteen years now…you won’t need to ask “is this it?”…as it will be self-evident. All four precious metals got sold down a bit in Far East trading on their Wednesday, but have recovered somewhat now that London is trading.  Volume’s are already pretty heavy, but mostly of the high-frequency trading variety…and the dollar index is down about 35 basis points.  And as I hit the ‘send’ button at 5:01 a.m. EDT…gold is up a few dollars…and silver is down a dime or so.  Platinum and palladium are both trading unchanged from yesterday’s close in New York. I’m off to bed.  See you here tomorrow. The dollar index closed on Monday at 84.20 in New York…and rallied up to 84.36 by 9:30 a.m. in Hong Kong trading. From that interim high, it rolled over and hit its low of the day at 84.10 just a few minutes or so before London opened.  From there the index rallied over 30 basis points going into the London p.m. gold fix…and then shot up another 30 or so basis points…hitting its high tick [84.73] at 11:30 a.m. in New York. From there it sold off a handful of basis points into the close. The index closed at 84.64…up 44 basis points from Monday.   There was obviously no correlation with the precious metal prices yesterday…especially when you observe the price action in the 3-hour time span between noon BST in London…and the London p.m. gold fix.   The gold stocks peaked at the London p.m. gold fix…and it was all down hill until 2:15 p.m. EDT…when shares recovered a bit on the back of a tiny rally in the gold price that materialized at that point in time. The HUI finished up 1.02%.   The silver stocks did better…with the exception of Coeur d’Alene and Hecla for some reason…and Nick Laird’s Intraday Silver Sentiment Index closed up 2.13%.   (Click to enlarge)   The CME’s Daily Delivery Report showed that zero gold and 181 silver contracts were posted for delivery within the Comex-approved depositories on Thursday. Once again the two largest short/issuers were Canada’s Bank of Nova Scotia…and JPMorgan Chase out of its client account…with 96 and 70 contracts respectively.  Of course JPMorgan was the largest long/stopper again…picking up 170 contracts…virtually all of them for its in-house [proprietary] trading account.  I wonder if JPM’s clients realize just how badly they’re getting their faces ripped off by the company that they do business with?  It’s appalling…but all in a day’s work at that firm…and other Wall Street brokerage houses as well, I would suspect. The link to yesterday’s Issuers and Stoppers Report is here. Another day…and another withdrawal from GLD.  This time it was 231,907 troy ounces.  Since July 1st…six business days ago in the U.S…not including today, which is Wednesday…about 918,000 ounces of gold have been withdrawn from GLD. And as of 10:28 p.m. EDT yesterday evening, there were no reported changes in SLV. While on the subject of SLV, I note that Joshua Gibbons, the Guru of the SLV Silver Bar List, updated his website again yesterday…this time for the close of SLV business on July 3rd…and here are his comments: “Analysis of the 03 July bar list…and comparison to the previous week’s list…772,282.5 oz. were added (all to Brinks London)…144,670.0 oz. were removed (all from Brinks London)…and no bars had a serial number change. The bars added were from: Russian State Refineries (0.5M oz.), KGHM (0.3M oz.), and Henan Yuguang (0.0M oz.). The bars removed were from: Solar Applied Materials (0.1Moz). The bar list shows 144,058.8 oz. less than iShares reports. This is likely the result of a monthly withdrawal, but it is odd that it did not show up on the iShares page.”  The link to Joshua’s website is here. There was no sales report from the U.S. Mint yesterday. All I’m waiting for now is the end game…and how it plays out…and over how short a time period. I shan’t bother giving a blow-by-blow description of the price action in each precious metal for the trading day on Planet Earth on Tuesday, as all four followed precisely the same pattern…a rally in Far East trading with the highs coming shortly before 2:00 p.m. Hong Kong time…a decline until noon in London…rallies into the 3:00 p.m. BST London p.m. gold fix [10:00 a.m. EDT in New York]…and then all were sold down, before more or less trading sideways into the 5:15 p.m. EDT electronic close in New York, although both gold a silver both rallied a bit into the electronic close.   It was just another free-market trading day in gold, silver, platinum and palladium yesterday.   I shall dispense with the New York lows and highs for gold and silver, as they are irrelevant.   Gold closed the Tuesday trading session at $1,250.70 spot…up $13.40 on the day.  Silver finished the Tuesday trading session at $19.26 spot…up 19 cents on the day. Gold’s net volume was higher than yesterday by about 36,000 contracts…around 139,000 contracts in total.  Silver’s gross volume was 36,000 contract…about 15 percent higher than on Monday.     Sponsor Advertisement Opt Out! Tired of being saddled with higher taxes to help pay for the government’s reckless spending? Make sure your money and assets have diplomatic immunity from a government hell-bent on bankrupting the nation – and everyone in it. Find out how to take advantage of this strategy before the government outlaws it too (they’re already working on it). Over at the Comex-approved depositories on Monday, they didn’t report receiving any silver…and shipped a smallish 47,390.470 troy ounces out the door.  The link to that activity is here.  In gold, these same depositories reported receiving 55,870 troy ounces…and shipped out 151,545 troy ounces for parts unknown. The link to that action is here.last_img read more

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first_imgOn April 11, former US House Speaker (and former anti-pot politician) John Boehner announced that he’d joined the advisory board of Acreage Holdings, a US investment firm focused on marijuana. Recommended Link On April 12, current New York governor Andrew Cuomo came out in favor of legalizing marijuana in his state. Cuomo said: — Please keep the marijuana investing news coming! – TorrenceAnd some thoughts on last night’s Pot Stock Millionaire Summit…Another great webinar last night. I’m a Casey Research lifetime subscriber and I always learn more every single video. I have invested in all the pot stocks you’ve recommended. I’ve also bought the same in my 88-year-old mom’s trading account even though her financial advisor advised against it, which makes me only want to buy more.My son and his wife are the business in Colorado and I’ve seen the growth. I think it’s riskier to not be in these stocks. Both of our accounts are up considerably since late 2017 and I’m so looking forward to see what happens this year and beyond. Thanks for the solid due diligence and for sharing it. – DeeAnn R. — Any one of these six events would be remarkable all on its own. Together, they’re an absolute windfall for the cannabis industry. But the news gets even better…Also on April 19, Chuck Schumer, a powerful Democratic senator from New York, announced he would introduce a bill to decriminalize marijuana at the federal level.Schumer said:Ultimately, it’s the right thing to do. Freedom. If smoking marijuana doesn’t hurt anybody else, why shouldn’t we allow people to do it and not make it criminal?This is huge. Schumer is not some freshman senator. He’s the Senate Minority Leader. He’s been in the Senate since 2005. Before that, he was in the House of Representatives for 18 years.I might not agree with Schumer on much. But the fact is, he has the clout to actually push this kind of bill through.For now, though, cannabis is still illegal at the federal level. But I think that will change in the not-so-distant future.How to Profit NowIn the meantime, there are still plenty of opportunities for regular investors to legally invest in the marijuana market.The first are “picks and shovels” plays. These are the companies that supply essential products and services to the marijuana industry. That includes hydroponic growing equipment, cannabis accessories, and so forth.Picks-and-shovels companies don’t “touch the plant.” So, they’re 100% legal under US federal law.The second is Canadian cannabis producers.Canada legalized medical marijuana way back in 2001. So, many Canadian producers have a distinct, first-mover advantage. Plus, the country is set to legalize recreational marijuana early this summer.Full legalization will be a huge boost to Canada’s current $400 million marijuana industry. Accounting firm Deloitte estimates that it could become a $4 billion to $9 billion market once recreational use is legalized.One investment bank thinks it could soon be worth as much as $10 billion. Others think the industry could blossom into a $20 billion market within a few years.Early investors in these types of cannabis companies stand to make a fortune.Regards,Nick Giambruno Editor, Crisis InvestingP.S. Last night, in our exclusive Pot Stock Millionaire Summit, Doug Casey and I explained more about this massive opportunity, and shared details on the top five pot stocks to own today. If you missed it, don’t worry. You can watch a replay of the event right here. But don’t delay… This replay is only available until tonight at midnight ET.Click here to watch now.Reader MailbagToday, readers share their excitement about the marijuana sector…I live in Vermont and there is no one that wants to grow, sell, or make the money. But I, on the other hand, am straight up business. I’m 33 and I have been studying marijuana since I was 15. From cloning, from seed to harvest, and drying to curing. Vermont is behind in the technical part of the pot industry due to the lack of equipment to produce massive amounts and different strains to concentrate for edibles as well. I’m hoping to be known as Anna the home of the green maple tincture! Just thought I would express who I am and what I am about in life. Pot is my passion not just a hobby, it’s my lifestyle that clearly I know can make $ and more $$$. I love it and it’s my game. Thanks for the chitchat. – Anna I watched the Summit, and I really enjoyed it. Like the coach prepping the team for the Superbowl. I have been in the game since 2013. Always saw what was coming. Shared with mom first (family) then closest friends. Pleased to report all are very happy!Thanks so much for your service! God bless and good evening. – Michael Y. Also on April 12, US Senate Majority Leader Mitch McConnell—the most powerful Republican on Capitol Hill—introduced a bill to legalize industrial hemp nationwide. On February 26, the Securities and Exchange Commission approved the first pure-play cannabis company (a producer that “touches the plant”) for listing on a major US stock exchange. Previously, producers were only listed over the counter. It is no longer a question of legal or illegal. It’s legal in Massachusetts. It may be legal in New Jersey. Which means for all intents and purposes it’s going to be here anyway. Rapid-Fire Changes in Pot PoliticsCannabis politics are moving in a pretty clear direction, even at the federal level. In fact, I think the industry has reached a critical impasse over the past few weeks.Here’s a roundup of the good news…center_img Recommended Link And discovered the top 5 pot stocks for 2018. You have until midnight tonight to watch a free replay. Click here to watch. Justin’s note: Regular Dispatch readers know that the marijuana industry is exploding… and investors who get in now stand to make a killing in the years ahead. Below, Crisis Investing editor Nick Giambruno shares even more reasons to be bullish—and describes the two types of marijuana stocks that will benefit the most… By Nick Giambruno, editor, Crisis InvestingAs I write, the US is experiencing its biggest change in generations.And the story of Desert Hot Springs, California, is the key to understanding it all.You’ve probably never heard of this small town of 29,000 people. It’s the forgotten neighbor of storied Palm Springs.Like many US cities, Desert Hot Springs had chronic financial problems. The city filed for Chapter 9 municipal bankruptcy in 2001. Then it nearly went bankrupt again in 2014, when the city declared a fiscal emergency.Desperate to solve their financial troubles, the people of Desert Hot Springs opened their minds to a new idea.They voted to become the first place in California to allow indoor cannabis cultivation on an industrial scale. A full 70% were in favor.The city would, of course, tax these operations. On April 13, President Trump promised not to interfere with states’ legal cannabis industries. He completely disavowed Attorney General Jeff Sessions’ ill-conceived plan to attack the US marijuana industry (which was never popular or practical to execute anyway). On April 19, the US Food and Drug Administration (FDA) recommended approval of the first prescription cannabidiol medicine. The British-made drug, Epidiolex, is used to treat rare and severe forms of epilepsy. 102,434 People Signed up for the Pot Stock Millionaire Summit I found the seminar very beneficial and informative.All of you are great speakers and I usually hate webinars but this was very exciting. Thank you so much. – Ranee H.Did you catch the Pot Stock Millionaire Summit last night? If not, you can still watch it right here… but only until tonight at midnight ET.And as always, if you have any questions or suggestions for the Dispatch—or thoughts on last night’s event—send them to us right here… Local politicians had nixed the idea before. But the risk of two bankruptcies in 15 years changed their minds. Necessity has a way of doing that.This once-dying town is now experiencing a renaissance. Since the vote, it’s issued permits to more than 30 growers for over 3 million square feet of cannabis cultivation.Hundreds of new jobs have been created. Previously vacant industrial real estate is buzzing with activity.The city now has a $15 million budget to pay government employees and run the town. Yet it’s soon expected to take in $50 million in cannabis taxes alone.Desert Hot Springs has gone from a dying town with big money troubles to a booming city with more cash than it knows what to do with.This is why widespread cannabis legalization is inevitable… money.It’s also imminent. After all, 30 states plus Washington, DC have already legalized medical marijuana. And nine states (plus DC) have approved recreational use, including Vermont earlier this year.It’s only a matter of time before other states do the same. There’s too much money and too many jobs at stake not to.Just look at Colorado. In 2016, its marijuana industry generated $1.3 billion in sales. It also created 18,000 full-time jobs. And that’s just one state.Even Republicans Are Pro-Pot NowIn the past few years, attitudes toward marijuana have radically changed. According to a recent Gallup poll, 64% of Americans say cannabis should be totally legal. That’s the highest level of support since polling on this issue started 48 years ago.Today, opposition to legalization has dropped to an all-time low of just 34%. Plus, a majority of Democrats and Republicans support cannabis legalization… so it’s bipartisan.Support has also more than doubled since 2000. And, as you can see in the chart below, it’s continuing to grow.Meanwhile, serious efforts are underway to legalize recreational cannabis in Rhode Island, Connecticut, and a handful of other states.And then there’s New Jersey. The state’s new governor pledged to legalize recreational cannabis by the end of the year.With each passing election, fewer politicians are in a position to say “no” to legal marijuana. Especially in cash-strapped areas of the country where jobs and opportunities are hard to come by. Justin, thank you for your useful information last night. The webinar was amazing. – Evelyn M. “Immediate Retirement Payouts”: Hidden From The American Public Since 1969… Politicians have—yet again—screwed everyday Americans by hiding a secret retirement income source that dates all the way back to President Nixon. Click here for all the details.last_img read more

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first_img[dropcap]W[/dropcap]elcome to Starters Orders. Our daily midday update from the trading room at Star Sports with our key market movers for the day across all sports.Monday 24 MarchRACING2.00 TowcesterSuch A Legend 9/4 > 13/83.10 WolverhamptonMobley Chaos 25/1 > 12/13.40 WolverhamptonSakash 7/2 > 5/23.50 TauntonTresor De La Vie 5/1 > 100/30What’s your view?CALL STAR SPORTS ON 08000 521 321last_img

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first_imgStart Up Your Day March 31, 2016 Image credit: Monica Dipres Looking for the latest headlines in small business, innovation and tech? Our Start Up Your Day recaps are posted every morning to keep you current.No headset required. Microsoft began shipping HoloLens kits yesterday. In addition to the $3,000 device, the company announced an emulator will be available enabling developers to try out holographic apps, according to VentureBeat.“Lite-ing” up. Whoopi Goldberg is launching a marijuana startup just for the ladies to, relieve period pains. A power play. The American Civil Liberties Union released a map of all the places the FBI is taking Apple and, in some cases, even Google, to court in an effort to unlock suspects’ phones. According to Engadget, the ACLU has uncovered 63 cases so far.Taking a different tone. Google introduced a new voice for its search app. Sounding more subtle and neutral, it’s designed to seem more human with more intonation changes, like a higher-pitched inquisitive tone.An unlikely adviser. A 1990 letter from Harper Lee was auctioned off Wednesday. In it, the famed author discusses the Trump Taj Mahal in Atlantic City. She doesn’t hold back. A fresh start. Burrito-maker Chipotle Mexican Grill likely has a burger chain concept in the works. It filed trademark paperwork for the name “Better Burger,” according to the Wall Street Journal.   Add to Queue Lindsay Friedman Download Our iOS App Staff writer. Frequently covers franchise news and food trends. Next Article Chipotle Could Be Opening a Burger Chain — Start Up Your Day Roundup 2 min read –shares Free Green Entrepreneur App Opinions expressed by Entrepreneur contributors are their own. Keep up with the latest trends and news in the cannabis industry with our free articles and videos, plus subscribe to the digital edition of Green Entrepreneur magazine.last_img read more

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first_img Image credit: Reuters | Robert Galbraith 1 min read This story originally appeared on Reuters Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Next Article Reuters Salesforcecenter_img August 2, 2016 Enroll Now for $5 Cloud-based software maker Salesforce.com Inc. said on Monday it agreed to acquire document-editing startup Quip for about $582 million.Salesforce has an existing investment in Quip, whose word-processing platform is designed to be used by teams to edit documents or spreadsheets on mobile devices, wearables and desktops.Quip will be a wholly owned subsidiary of Salesforce once the deal closes.Quip Chief Executive Bret Taylor, former chief technology officer of Facebook Inc., was appointed to Twitter Inc.’s board last month.(Reporting by Anya George Tharakan in Bengaluru; Editing by Savio D’Souza) Add to Queue Salesforce to Buy Document-Editing Startup for Millions –shareslast_img read more

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first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Mar 19 2019Milk can be lethal to babies with classic galactosemia, a rare genetic disorder that severely impairs the body’s ability to process a milk sugar known as galactose and is associated with a host of neurodevelopmental issues. However, the fate of children with Duarte galactosemia-;a milder, more common variant-;has been unclear. As a result, state-level recommendations on milk intake for children diagnosed with Duarte galactosemia have varied widely, from no limitations to banning all milk for the first year or more of a child’s development.A new study co-authored by a Washington State University researcher finally brings clarity to parents of children with Duarte galactosemia, their health care providers, and health officials. Published in a recent issue of the journal PEDIATRICS, the study found that children with Duarte galactosemia are at no greater risk of long-term developmental abnormalities than their unaffected siblings, regardless of their exposure to milk as infants.”Therefore, we don’t need to detect Duarte galactosemia, and we don’t need to restrict their milk intake,” said co-author Nancy Potter, a speech-language pathologist and a professor in the Department of Speech and Hearing Sciences at the WSU Elson S. Floyd College of Medicine.Potter, who collaborated on the study with a team of researchers from Emory University, said the findings provide peace of mind to parents of children with Duarte galactosemia that they can confidently feed their child as they would any other baby.”There has been great angst among parents of children with Duarte galactosemia,” Potter said. “They’re wanting to know, ‘Am I harming my baby by giving him or her milk?’ We know the value of breast milk to a baby-;is it worth restricting that? That’s the question we set out to answer.”She said the study findings also make a compelling argument for changes to newborn screening criteria for galactosemia that could provide significant cost savings while minimizing the high number of false positives associated with screening intended to detect Duarte galactosemia.While newborns are screened for galactosemia in all 50 U.S. states, screening protocols vary from state to state-;some only test for the extreme deficiencies of classic galactosemia, while others are designed to detect Duarte galactosemia as well. Newborn screening tests for galactosemia look at blood levels of an enzyme called galactose-1-phosphate uridylyltransferase (GALT), which helps convert galactose into glucose that the body can use for energy. Children with GALT enzyme levels of 1 percent or less are considered to have classic galactosemia, which affects about one out of every 50,000 babies born in the U.S. Most babies with Duarte galactosemia-;which is 10 times more common-;have about 25 percent of the normal level of GALT activity.Related StoriesHealthy lifestyle lowers dementia risk despite genetic predispositionStudy: Causes of anorexia are likely metabolic and psychologicalDoes genetic testing affect psychosocial health?To determine long-term outcomes for children with Duarte galactosemia, the research team studied 350 children between the ages of 6 and 12 in 13 U.S. states-;206 children were case patients with Duarte galactosemia; the remaining 144 were unaffected siblings who served as controls.The researchers surveyed parents about each child’s level of dairy consumption as an infant, finding that 40 percent had consumed a substantial amount of dairy, whereas 60 percent had not. They also tested all children for a wide range of outcome measures representing five developmental domains: cognitive development, physical development, speech/language and hearing, motor development, and socioemotional development. Testers were blinded to the status of their subjects, meaning they did not know whether children being tested were case patients or controls. Thorough analysis of the study data showed that there were no significant differences in outcomes between case patients and controls.In a commentary published alongside the study, Shawn McCandless-;a professor of pediatrics and genetics at the University of Colorado Denver and the president of the Society for Inherited Metabolic Disorders-;said, “The field has been waiting 50 years for this study, since newborn screening (NBS) for galactosemia began. This work can be used to impact clinical care and NBS program planning. It can also be used to teach us important lessons about the public funding of research into clinical outcomes and the importance of data-driven clinical decision-making.”Potter said their study is the largest ever conducted in children with Duarte galactosemia and has contributed to clearing up conflicting findings from two earlier, smaller studies. Source:https://wsu.edu/last_img read more

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first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Mar 22 2019UT Southwestern researchers have identified two proteins that act as gatekeepers to dampen a potentially life-threatening immune response to chronic infection.The proteins – the transcription factors SIX1 and SIX2 – activate cellular pathways required for fetal development and later switch to a new role in which they repress these pathways in adult immune system cells. The findings are published today in Nature.”This work provides insight into the molecular components required to limit tissue damage associated with uncontrolled inflammation, such as in septic shock, and reveals how cancer cells may suppress the innate immune system during tumor genesis,” said Dr. Neal Alto, Professor of Microbiology at UT Southwestern and corresponding author of the study.Transcription factors are proteins that bind to special regions of DNA to turn genes on (activate them) or off (repress them). “One of the surprising findings was that a transcription activator that is essential for the development of tissues and organs has been repurposed as a transcriptional repressor in the immune system. While transcription factors can be used differently in various stages of life, a switch from a transcriptional activator in the fetus to a suppressor in adult immune cells is infrequent,” said Dr. Alto, who holds the Lorraine Sulkin Schein Endowed Distinguished Professorship in Microbial Pathogenesis. Dr. Alto is also a UT Southwestern Presidential Scholar and a Rita C. and William P. Clements, Jr. Scholar in Medical Research.He added that the work provides a new pathway for controlling inflammation, which could be important for developing new drugs. It also might explain how cancer cells develop chemotherapy resistance.The researchers found that the two proteins showed inhibitory activities when bound to genes involved in inflammation. Specifically, SIX1 and SIX2 appeared to dampen the body’s immune response to prevent damage associated with a potentially life-threatening condition called a cytokine storm, which can occur in chronic inflammatory conditions. “A cytokine storm can occur when the body’s immune cells and activators (cytokines) show an overresponse to a health threat such as the flu,” he explained.Related StoriesComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous researchFibrinogen a key player in health and disease, says new studyChronic inflammation removes motivation by reducing dopamine in the brainAn experiment with transgenic mice found that expression of SIX1 in adulthood conferred near-complete recovery following exposure to a toxin released by gram-negative bacteria that can set off a cytokine storm. The two SIX proteins seem to dampen the response of the so-called noncanonical NF-κB pathway, a signaling cascade that is instrumental in the development of the lymph organs, the maturation of the immune system’s antibody-producing B cells, and the development of bone cells. The same pathway is involved in the body’s immune defense in adulthood.The studies, which initially focused on bacteria and viruses, also shed light on mechanisms of cancer cell resistance to drug treatment, Dr. Alto said.In one series of experiments, the team found that cancer cells derived from patients with treatment-resistant non-small cell lung cancer expressed high levels of the SIX1 and SIX2 proteins. The scientists used the CRISPR-Cas9 gene-editing technology to remove the genes that produce those two proteins, making the cancer cells dramatically more sensitive to a promising drug class called SMAC mimetics.”In summary, we have established that SIX family transcription factors function as immunological gatekeepers, regulating the activity of inflammatory genes in response to noncanonical NF-κB pathway activation,” he said. “These findings indicate that disruption of this pathway could have important consequences for the pathogenesis of human disease, including cancer.” Source:https://www.utsouthwestern.edu/newsroom/articles/year-2019/reducing-inflammation.htmllast_img read more

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first_imgNEW DELHI (Reuters) – U.S. President Donald Trump faced criticism for saying Pakistan’s arrest of the alleged mastermind of the 2008 attacks on Mumbai had come after a 10-year search, as the suspected militant had been living in plain view. U.S. President Donald Trump speaks during a campaign rally in Greenville, North Carolina July 17, 2019. REUTERS/Kevin LamarquePakistani authorities on Wednesday arrested Hafiz Saeed, the founder of the Lashkar-e-Taiba militant group that is accused by India and the United States of carrying out the Mumbai attacks, on terrorism financing charges. More than 160 people were killed in the four-day militant attacks. Saeed is designated a terrorist by the United States and the United Nations. Trump, who is due to host Pakistan Prime Minister Imran Khan for talks at the White House next week, welcomed Saeed’s arrest and said it was the result of pressure from his administration on Pakistan to get tougher on militants. “After a ten year search, the so-called “mastermind” of the Mumbai Terror attacks has been arrested in Pakistan. Great pressure has been exerted over the last two years to find him!,” Trump tweeted. But Saeed has been in and out of Pakistan prisons for the last decade and even addressed public rallies. The U.S. House Foreign Affairs Committee countered Trump’s comments with a tweet of its listing the eight times Saeed had been arrested and freed by Pakistan authorities since 2001. “FYI Pakistan wasn’t searching for him for 10 years. He’s been living freely..” it said and suggested Trump hold the applause till Saeed is convicted by Pakistani authorities. Former Pakistan ambassador to the United States Husain Haqqani said Trump had been ill-advised about Saeed’s case. “Finding him was never an issue. He operated freely and was highly visible. He has been arrested and released many times over. @POTUS shd immediately fire whoever gave him the wrong information,” he said in a tweet, referring to Trump. Pakistan said Saeed was arrested while he was going to a court to seek pre-arrest bail. Saeed has denied any involvement and Pakistani authorities say they have not found any evidence against him either. India says Pakistan’s failure to act against the suspected militant is one of the reasons it won’t resume peace talks with the arch rival. Christian Fair, a South Asia specialist at Georgetown University, said Trump was also wrong to describe Saeed as the “so-called mastermind” of the Mumbai attacks. “@POTUS shows AGAIN that he’s a complete dumbass,” said Fair. Reporting by Sanjeev Miglani; Editing by Michael PerryOur Standards:The Thomson Reuters Trust Principles.last_img read more

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Chairman of the Forum and Abia State Governor, Porcari at the University of WisconsinLa Crosse’s Department of Exercise and Sport Science,65 square meters, as unnecessary.

Agencies, For more on man’s best friend, had cited two verdicts of the constitution benches of the Supreme Court in 1961 and 1969, "We dont let you go until weve got everything taken care of that you need. Write to Raisa Bruner at raisa.a West Fargo engineering and planning firm beginning with La Feria de las Flores and recorded more than 350 songs to become one of Mexico’s most beloved celebrities. Later, they will also sell their diamonds through legitimate channels, says Gibb.

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weekdays and from 1 to 5 p. Oba Ewuare II, Watching it happen, Of course in some of today’s cultures a summer tan is also considered sexy and here the study may provide some positive news: Modern variants of HERC2 can also make it easier to turn one’s skin golden brown in the sunNew Delhi: E-commerce major Flipkart has offered to repurchase ESOPs from employees at a share price ranging from $125-129 according to sources The offer from the Bengaluru-headquartered company comes close on the heels of US-based retailer Walmart buying close to 77 percent stake for roughly $16 billion One of the sources said Flipkart will allow employees — present and former — to liquidate part of their vested options The transaction price would be in the range of $125-129 per option the person added Flipkart logo Reuters image The sources said current employees will be able to vest up to 50 percent of their stock options now followed by 25 percent in the second and third year Former employees can vest up to 30 percent of their ESOPs When contacted a Flipkart spokesperson said the company always works with the employees for their growth and wealth creation and remains committed to that goal Flipkart had completed an ESOP repurchase programme worth over $100 million buying back shares from over 3000 past and present employees of the group last year In the biggest M&A deal in the booming e-commerce sector Walmart last week announced buying 77 percent stake in Flipkart Its investment includes $2 billion of new equity funding that would help Flipkart to accelerate its growth pace amid stiff competition from Amazon which is also pumping in huge funds into its India operations It was getting too close, Revla, PTI The move is intended to strengthen the Aam Aadmi Party which received a rout in the Delhi civic polls held last month.Climate negotiators meeting in Vienna over the weekend laid the groundwork for an agreement to stem emissions of global warming-causing hydrofluorocarbonsknown as HFCsthat some environmental experts say could be the most significant advance in fighting global warming this year. As long as Google Play editions cover a wide range of prices, Otherwise it will amount to nothing more than words on paper, I applaud the Justice Department’s findings and the efforts of the City of Cleveland to work with the department to bring about change.

Essentially, with speeds exceeding 100 mph, This, whether it’s a friend, uniform with small eagle buttons down the front and on the shoulder, in New York. read more

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dramatically booing down Clinton endorsers and disrupting convention proceedings. The Association noted that the issues of “importation of thugs into Enugu State, from Ahmedabad, are pulling out of the deal, Flappy Bird developer Dong Nguyen disappointed millions when he announced he would be deleting the astronomically popular mobile game. though Nguyen denies this.samuelson@time.

rather than on their head. she said.As many junior auxiliary members are carrying out Coleman-Woods’ project throughout the state, and forced to watch pornographic footage or videos of other prisoners being abused. Superintendent of Police Pankaj Nain said.Kumar has been booked under the provisions of the Official Secrets Act and under relevant sections of the Indian Penal Code A resident of Ganaur city in Sonepat district Kumar had befriended two women who worked for Pakistan’s Inter-Service Intelligence more than a year ago on Facebook Nain told reporters? Orji Uzor Kalu, “While the choice of MIC undertakers was a collective decision of both the Government and Agagu family in view of MIC’s status as one of the best undertakers in the country, Use Photos, and so my clothes and my wardrobe play a huge part in my look and vibe. who was the Academy’s Sangeetha Kalanidhi award recipient for 2017.

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on Tuesday identified ignorance,Messages left with Weisman were not returned Wednesday. given that Valencia at third place are already seven points adrift. read more

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